Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma
Caspase-8 is a key player in extrinsic apoptosis and its activity is often downregulated in cancer.However, human Caspase-8 expression is retained in some tumors, including kali ws 6.2 glioblastoma (GBM), suggesting that it may support cancer growth in these contexts.GBM, the most aggressive of the gliomas, is characterized by extensive angiogenesi